Aldose Reductase Inhibition Effect of Phenolic Compounds Isolated from Paulownia coreana Bark*
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چکیده
Nine compounds, caffeic acid, naringenin, apigenin, luteolin, kaempferol, verbascoside, isoverbascoside, isocampneoside II, and cistanoside F, were isolated from the EtOAc and n-BuOH fractions of P. coreana bark. The structures of these compounds (1-9) were elucidated by spectroscopic methods and literature data. All the isolates were subjected to in vitro bioassay to evaluate their inhibitory activity against rat lens aldose reductase. Among these, compounds 6 and 8 indicated the significant inhibitory activity on rat lens aldose reductase with IC50 values of 2.67 and 5.59 μM, respectively. Especially, The inhibition activity of acteoside was 3.9 times better than that of quercetin as a positive control (10.6 μM). These results suggested that phenylethanoid glycosides are likely to be the potential compounds for the prevention and/or treatment of diabetic complications.
منابع مشابه
Inhibition of aldose reductase by phenylethanoid glycoside isolated from the seeds of Paulownia coreana.
Aldose reductase (AR) inhibitors have considerable therapeutic potential against diabetic complications and do not increase the risk of hypoglycemia. Through bioassay-guided fractionation of the 70% acetone extract obtained from Paulownia coreana seeds, phenylpropanoid glycosides (compounds 1-4) and 5 phenolic compounds were isolated (compounds 5-9). Their structures were determined on the basi...
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متن کاملLee et al., Inhibitory effect and mechanism of antiproliferation of isoatriplicolide tiglate (PCAC) from Paulownia Coreana. Molecules 2012, 17, 5945-5951: a note regarding Paulownia coreana.
I read with interest the article by Lee et al. entitled " Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana " [1]. This article is quite interesting and the authors should be complimented for the significant amount of work they have done. The purpose of this letter is to call attention to the need for some clarification on the name of...
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